EvoTol: a protein-sequence based evolutionary intolerance framework for disease-gene prioritization


Recommended citation: http://nar.oxfordjournals.org/content/43/5/e33.short

Abstract Methods to interpret personal genome sequences are increasingly required. Here, we report a novel framework (EvoTol) to identify disease-causing genes using patient sequence data from within protein coding-regions. EvoTol quantifies a gene's intolerance to

Number of citations: 6